IGFBP3 anticorps

N° du produit ABIN7126549

Cet anticorps anti-IGFBP3 est un anticorps Monoclonal produit chez le Souris, détectant IGFBP3 dans IF et FACS. Convient pour Humain.

Aperçu rapide pour IGFBP3 anticorps (ABIN7126549)

Antigène: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGFBP3 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-IGFBP3 anticorps

Specificité: The Insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80 % of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human full-length IGFBP3 protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: U-87 or A-431 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur IGFBP3

Antigène: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Autre désignation: IGFBP3

Sujet: Acid stable subunit of the 140 K IGF complex, Binding protein 29, Binding protein 53, BP53, Growth hormone dependent binding protein, IBP3, IGF binding protein 3, IGFBP3, Insulin-like growth factor binding protein 3 precursor,IGFBP3
Cellular localisation: Secreted. Localized to vesicles, cytosol and nucleoplasm.

Poids moléculaire: 40/44kDa

ID gène: 3486, 450230, 697535

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding