MXI1 anticorps

N° du produit ABIN7126729

Cet anticorps anti-MXI1 est un anticorps Souris Monoclonal détectant MXI1 dans WB, IF et FACS. Adapté pour Humain.

Aperçu rapide pour MXI1 anticorps (ABIN7126729)

Antigène: MXI1 (MAX Interactor 1 (MXI1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MXI1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-MXI1 anticorps

Specificité: It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1 (also designated Mad 2), Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad- binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.

Réactivité croisée (Details): Human

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human MXI1 protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or K562 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur MXI1

Antigène: MXI1 (MAX Interactor 1 (MXI1))

Autre désignation: MXI1

Sujet: BHLHc11, Class C basic helix-loop-helix protein 11, MAX dimerization protein 2 (MAD2), MAX interacting protein 1, Max interactor 1, Max related transcription factor, MXD2, MXI, MXI1 protein,MXI1
Cellular localisation: Nucleus.

Poids moléculaire: 26/22/33/21 kDa (isoforms)

ID gène: 4601

UniProt: P50539

Pathways: Maintenance of Protein Location