PIK3R2 anticorps (AA 520-720)

N° du produit ABIN7126793

Cet anticorps Souris Monoclonal détecte spécifiquement PIK3R2 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PIK3R2 anticorps (AA 520-720) (ABIN7126793)

Antigène: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PIK3R2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: PIK3R2-292

Détail du produit anti-PIK3R2 anticorps

Épitope: AA 520-720

Fonction: PIK3R2 / Phosphoinositide-3-kinase regulatory subunit 2 Antibody

Specificité: Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85°™ and p85 æ), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110°™ and p110 æ interact with p85°™, and p110°™ has also been shown to interact with p85 æ in vitro. p110 79oΩL expression is restricted to white blood cells. It has been shown to bind p85°™ and p85 æ, but it apparently does not phosphorylate these subunits. p110 79oΩL seems to have the capacity to autophosphorylate. p110Á does not interact with the p85 subunits. It has been shown to be activated by °™ and æÁ heterotrimeric G proteins.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human PIK3R2 protein (around aa 520-720) (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human spleen or bladder.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PIK3R2

Antigène: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Autre désignation: PIK3R2

Sujet:

p85 beta, P85B, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta), Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta), PI3 kinase p85 beta subunit, PI3K regulatory subunit beta, PIK3R2, PtdIns-3-kinase regulatory subunit p85-beta

Human spleen or bladder.

Poids moléculaire: 85kDa

ID gène: 5296, 371344

UniProt: O00459

Pathways: VEGF Signaling, BCR Signaling