Recombinant PARVG anticorps

N° du produit ABIN7126931

Détail du produit anti-PARVG anticorps

Antigène: PARVG (Parvin, gamma (PARVG))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PARVG est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: The parvin family, including i±-parvin, i²-parvin and i³-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, i±-actinin and testicular kinase 1. i±-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of i±-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. i²-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-i³-parvin complex is essential for the establishment of cell polarity required for leukocyte migration.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: GST-tagged recombinant protein corresponding to human Gamma-parvin

Isotype: IgG

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cell lysate.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur PARVG

Antigène: PARVG (Parvin, gamma (PARVG))

Autre désignation: PARVG (PARVG Produits)

Synonymes: anticorps PARVG, anticorps AI413459, anticorps parvin gamma, anticorps parvin gamma S homeolog, anticorps parvin, gamma, anticorps PARVG, anticorps parvg.S, anticorps Parvg

Sujet: Gamma parvin, PARVG,Gamma-parvin (PARVG)
Cellular localisation: Cytoplasm. Cell Surface.

Poids moléculaire: 37kDa

ID gène: 64098

UniProt: Q9HBI0