SET/TAF-I anticorps

N° du produit ABIN7126932

Détail du produit anti-SET/TAF-I anticorps

Antigène: SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SET/TAF-I est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Specificité: Protein phosphatase 2A (PP2A) is a major mammalian protein serine/threonine phosphatase that regulates diverse cellular processes. Inhibitor 1 of PP2A (I1PP2A) and inhibitor 2 of PP2A (I2PP2A), which share large sequence similarity, are heat-stable protein inhibitors of the cellular phosphatase activity of PP2A. I1PP2A and I2PP2A were initially characterized as putative HLA class II associated proteins Phap I and Phap II. These inhibitor proteins act noncompetitively to selectively inhibit PP2A, but do not affect the phosphatase activity of the related proteins PP1, PP2B and PP2C. The I1PP2A protein is localized to both the cytoplasm and the nucleus. In contrast, I2PP2A is located predominantly in the nucleus and is highly expressed in Wilms tumor cells. Transient expression of I2PP2A in HEK-293 cells leads to an increase in the DNA binding activity of the proto-oncogene c-Jun.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human SET protein

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or HepG2 cells.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur SET/TAF-I

Antigène: SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

Autre désignation: SET (SET Produits)

Synonymes: anticorps 2PP2A, anticorps I2PP2A, anticorps IGAAD, anticorps IPP2A2, anticorps PHAPII, anticorps TAF-I, anticorps TAF-IBETA, anticorps 2610030F17Rik, anticorps 5730420M11Rik, anticorps AA407739, anticorps I-2PP2A, anticorps StF-IT-1, anticorps 2pp2a, anticorps i2pp2a, anticorps igaad, anticorps ipp2a2, anticorps phapii, anticorps set, anticorps set-a, anticorps set-b, anticorps taf-ibeta, anticorps wu:fb30g11, anticorps wu:fd16c08, anticorps SET nuclear proto-oncogene, anticorps SET nuclear oncogene, anticorps SET translocation, anticorps SET nuclear proto-oncogene L homeolog, anticorps SET nuclear proto-oncogene b, anticorps SET, anticorps Set, anticorps LOC403555, anticorps set.L, anticorps setb

Sujet: 2PP2A, HLA DR associated protein II, IGAAD, Inhibitor of granzyme A activated DNase, inhibitor-2 of protein phosphatase-2A, IPP2A2, PHAPII, Phosphatase 2A inhibitor I2PP2A, protein phosphatase type 2A inhibitor, TAFI, Template-Activating Factor-I, chromatin remodelling factor, SET nuclear oncogene, SET translocation (myeloid leukemia-associated),SET
Cellular localisation: Cytoplasm > cytosol. Endoplasmic reticulum. Nucleus > nucleoplasm.

Poids moléculaire: 39kDa

ID gène: 6418, 436687

UniProt: Q01105

Pathways: Apoptose