Thyroperoxidase anticorps (AA 685-804)

N° du produit ABIN7127019

Cet anticorps Souris Monoclonal détecte spécifiquement Thyroperoxidase dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Thyroperoxidase anticorps (AA 685-804) (ABIN7127019)

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thyroperoxidase est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: TPO-3701

Détail du produit anti-Thyroperoxidase anticorps

Épitope: AA 685-804

Fonction: TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody

Specificité: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human TPO (around aa 685-804) (Exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human thyroid carcinoma

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Thyroperoxidase

Antigène: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Autre désignation: TPO

Classe de substances: Viral Protein

Sujet:

MSA, TDH2A, Thyroid microsomal antigen, Thyroid peroxidase, Thyroperoxidase, TPO, TPX

Human thyroid carcinoma

Poids moléculaire: 100kDa

ID gène: 7173, 467554

UniProt: P07202

Pathways: Thyroid Hormone Synthesis