MED7 anticorps
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- Antigène Voir toutes MED7 Anticorps
- MED7 (Mediator Complex Subunit 7 (MED7))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp MED7 est non-conjugé
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Application
- ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
- Specificité
- MED7, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, MED7 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, MED7 regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. MED7 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases MED7 mRNA-binding affinity. Defects or deletions in the gene encoding MED7 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of MED7 exist due to alternative splicing events.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant full-length human MED7 protein
- Isotype
- IgG2b
- Top Product
- Discover our top product MED7 Anticorps primaire
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- Indications d'application
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Known_Application: ELISA (use assay dependent concentration), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL),Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, U-251 MG or CACO-2 cells.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- MED7 (Mediator Complex Subunit 7 (MED7))
- Autre désignation
- MED7 (MED7 Produits)
- Synonymes
- anticorps ARC34, anticorps CRSP33, anticorps CRSP9, anticorps 1110063B05Rik, anticorps Crsp33, anticorps Crsp9, anticorps crsp9, anticorps wu:fd99d12, anticorps zgc:56241, anticorps crsp9-A, anticorps med7-a, anticorps mediator complex subunit 7, anticorps mediator complex subunit 7 L homeolog, anticorps mediator complex subunit, anticorps mediator complex subunit Med7, anticorps MED7, anticorps Med7, anticorps med7, anticorps med7.L
- Sujet
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Activator recruited cofactor 34 kDa component, ARC34, Cofactor required for Sp1 transcriptional activation, subunit 9, 33 kDa, CRSP complex subunit 9, CRSP9, hMED7, Mediator of RNA polymerase II transcription subunit 7, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33,MED7
Cellular localisation: Nucleus. Nuclear bodies. - Poids moléculaire
- 27.2kDa
- ID gène
- 9443, 279902
- UniProt
- O43513
- Pathways
- Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
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