MED7 anticorps

N° du produit ABIN7863632

Cet anticorps Souris Monoclonal détecte spécifiquement MED7 dans ELISA, FACS et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MED7 anticorps (ABIN7863632)

Antigène: MED7 (Mediator Complex Subunit 7 (MED7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MED7 est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-MED7-1B8

Détail du produit anti-MED7 anticorps

Fonction: MED7 Antibody

Specificité: MED7, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, MED7 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, MED7 regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. MED7 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases MED7 mRNA-binding affinity. Defects or deletions in the gene encoding MED7 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of MED7 exist due to alternative splicing events.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human MED7 protein

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur MED7

Antigène: MED7 (Mediator Complex Subunit 7 (MED7))

Autre désignation: MED7

Sujet:

Activator recruited cofactor 34 kDa component, ARC34, Cofactor required for Sp1 transcriptional activation, subunit 9, 33 kDa, CRSP complex subunit 9, CRSP9, hMED7, Mediator of RNA polymerase II transcription subunit 7, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33

HeLa, U-251 MG or CACO-2 cells.

Poids moléculaire: 27.2kDa

ID gène: 9443, 279902

UniProt: O43513

Pathways: Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha