Recombinant FEN1 anticorps

N° du produit ABIN7127487

Détail du produit anti-FEN1 anticorps

Antigène: FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FEN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human FEN1

Clone: 4D9

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FEN1

Antigène: FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

Autre désignation: FEN1 (FEN1 Produits)

Synonymes: anticorps FEN-1, anticorps FEN1, anticorps AW538437, anticorps MF1, anticorps RAD2, anticorps cb879, anticorps fen-1, anticorps fen1, anticorps mf1, anticorps rad2, anticorps xFEN1a, anticorps flap structure-specific endonuclease 1, anticorps flap endonuclease 1-like, anticorps Flap endonuclease-1, anticorps 5'-3' exonuclease family protein, anticorps flap structure specific endonuclease 1, anticorps flap structure-specific endonuclease 1 L homeolog, anticorps nuclease, Rad2 family, anticorps FEN1, anticorps LOC100808044, anticorps Bm1_49605, anticorps AT5G26680, anticorps Fen1, anticorps fen1, anticorps fen1.L

Sujet:

Background: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Aliases: Flap endonuclease 1UniRule annotation, DNase IV, Flap structure-specific endonuclease 1UniRule annotation, FEN1

UniProt: P39748

Pathways: Telomere Maintenance, Réparation de l'ADN, DNA Replication, Synthesis of DNA