Recombinant TERT anticorps

N° du produit ABIN7127839

Cet anticorps anti-TERT est un anticorps Lapin Monoclonal détectant TERT dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour Recombinant TERT anticorps (ABIN7127839)

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TERT est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 5C11

Détail du produit anti-TERT anticorps

Fonction: TERT Recombinant Monoclonal Antibody

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human TERT

Isotype: IgG

Information d'application

Indications d'application: IHC:1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TERT

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Autre désignation: TERT

Sujet:

Background: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

Aliases: Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2), TERT, EST2 TCS1 TRT

UniProt: O14746

Pathways: Telomere Maintenance