MAPT anticorps

N° du produit ABIN7138004

Cet anticorps Lapin Polyclonal détecte spécifiquement MAPT dans WB et ELISA. Il présente une réactivité envers Rat.

Aperçu rapide pour MAPT anticorps (ABIN7138004)

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MAPT anticorps

Fonction: Mapt Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Immunogène: Peptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: Mapt

Sujet:

Background: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Johnson , G.V. and Stoothoff , W.H. (2004) J. Cell Sci. 117, 5721-5729.
Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476.
Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.

Aliases: Mapt antibody, Mtapt antibody, Tau antibody, Microtubule-associated protein tau antibody, Neurofibrillary tangle protein antibody, Paired helical filament-tau antibody, PHF-tau antibody

UniProt: P19332

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size