CDC25B anticorps (pSer149)

N° du produit ABIN7138432

Cet anticorps anti-CDC25B Polyclonal Lapin (ABIN7138432) détecte spécifiquement CDC25B dans WB et ELISA. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour CDC25B anticorps (pSer149) (ABIN7138432)

Antigène: CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC25B est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CDC25B anticorps

Épitope: pSer149

Fonction: Phospho-Cdc25b (Ser149) Antibody

Réactivité croisée: Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Peptide sequence around phosphorylation site of Serine 149 (F-R-S(p)-L-P) derived from Mouse Cdc25B.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CDC25B

Antigène: CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))

Autre désignation: Cdc25b

Sujet:

Background:

Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.

Li G, et al. (2010) Retrovirology.7:59.
Wang Z,et al. (2010) BMC Cancer.10:233.
Lucci MA,et al. (2010) Cell Oncol.32(5-6):361-72.

Aliases: CDC25B

UniProt: Q9DBN8

Pathways: Cycle Cellulaire, M Phase, Autophagy