FBXL3 anticorps (pSer320)

N° du produit ABIN7138554

L’anticorps Lapin Polyclonal anti-FBXL3 a été validé pour WB et ELISA. Il convient pour détecter FBXL3 dans des échantillons de Humain.

Aperçu rapide pour FBXL3 anticorps (pSer320) (ABIN7138554)

Antigène: FBXL3 (F-Box and Leucine-Rich Repeat Protein 3 (FBXL3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXL3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FBXL3 anticorps

Épitope: pSer320

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 320 (S-V-S(p)-K-D) derived from Human FBXL3.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FBXL3

Antigène: FBXL3 (F-Box and Leucine-Rich Repeat Protein 3 (FBXL3))

Autre désignation: FBXL3

Sujet:

Background:

 Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.

 

1)Busino L., Bassermann F., Maiolica A., Lee C., Nolan P.M., Godinho S.I., Draetta G.F., Pagano M. Science 316:900-904(2007)                                          

2)Yoo S.H., Mohawk J.A., Siepka S.M., Shan Y., Huh S.K., Hong H.K., Kornblum I., Kumar V., Koike N., Xu M., Nussbaum J., Liu X., Chen Z., Chen Z.J., Green C.B., Takahashi J.S.Cell 152:1091-1105(2013)

 

Aliases: F box and leucine rich repeat protein 3 antibody; F box and leucine rich repeat protein 3A antibody; F box protein Fbl3a antibody; F-box and leucine-rich repeat protein 3A antibody; F-box/LRR-repeat protein 3 antibody; F-box/LRR-repeat protein 3A antibody; FBL3 antibody; FBL3A antibody; Fbxl3 antibody; FBXL3_HUMAN antibody; FBXL3A antibody

UniProt: Q9UKT7

Pathways: Photoperiodism