IRF3 anticorps (pSer386)

N° du produit ABIN7138590

Détail du produit anti-IRF3 anticorps

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Épitope: pSer386

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRF3 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of Serine 386(A-S-S(p)-L-E) derived from Human IRF-3.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IRF3

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Autre désignation: IRF3 (IRF3 Produits)

Synonymes: anticorps irf3, anticorps IRF3, anticorps C920001K05Rik, anticorps IRF-3, anticorps interferon regulatory factor 3, anticorps interferon regulatory factor 7, anticorps irf3, anticorps IRF3, anticorps irf-3, anticorps Irf3, anticorps IRF7

Sujet:

Background:

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Au W.W.-C., Proc. Natl. Acad. Sci. U.S.A. 92:11657-11661(1995).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Bellingham J., Ann. Hum. Genet. 62:231-234(1998).

Aliases: IIAE7 antibody, Interferon regulatory factor 3 antibody, IRF 3 antibody, IRF-3 antibody, IRF3 antibody, IRF3_HUMAN antibody, MGC94729 antibody

UniProt: Q14653

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades