alpha Adducin anticorps (pSer726)

N° du produit ABIN7138686

L’anticorps Lapin Polyclonal anti-alpha Adducin a été validé pour WB, IHC, ELISA et IF. Il convient pour détecter alpha Adducin dans des échantillons de Humain.

Aperçu rapide pour alpha Adducin anticorps (pSer726) (ABIN7138686)

Antigène: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha Adducin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-alpha Adducin anticorps

Épitope: pSer726

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 726 (T-P-S(p)-F-L) derived from Human ADD1.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur alpha Adducin

Antigène: alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))

Autre désignation: ADD1

Sujet:

Background: Adducins are a family of cytoskeleton proteins encoded by three genes (a, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. a- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. a- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms, however, not all variants have been fully described.

Pariser H, et al. Proc Natl Acad Sci USA 2005 Aug 30, 102(35): 12407-12
Tamaru S, et al. Biochem Biophys Res Commun 2005 Jul 01, 332(2): 347-51
Barkalow KL, et al. J Cell Biol 2003 May 12, 161(3): 557-70

Aliases: ADD A antibody, ADD1 antibody, ADDA antibody, ADDA_HUMAN antibody, Adducin 1 (alpha) antibody, Alpha adducin antibody, Alpha-adducin antibody, Erythrocyte adducin alpha subunit antibody, Erythrocyte adducin subunit alpha antibody, MGC3339 antibody, MGC44427 antibody, OTTHUMP00000151163 antibody, OTTHUMP00000151164 antibody, OTTHUMP00000151165 antibody, OTTHUMP00000218664 antibody, OTTHUMP00000218665 antibody

UniProt: P35611

Pathways: Negative Regulation of Hormone Secretion, Regulation of Actin Filament Polymerization, Regulation of Lipid Metabolism by PPARalpha, ER-Nucleus Signaling