LIM Domain Kinase 1 anticorps (pThr508)

N° du produit ABIN7138862

Cet anticorps Lapin Polyclonal détecte spécifiquement LIM Domain Kinase 1 dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour LIM Domain Kinase 1 anticorps (pThr508) (ABIN7138862)

Antigène: LIM Domain Kinase 1 (LIMK1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIM Domain Kinase 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-LIM Domain Kinase 1 anticorps

Épitope: pThr508

Fonction: Phospho-LIMK1 (Thr508) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of threonine 508 (R-Y-T(p)-V-V) derived from Human LIMK1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LIM Domain Kinase 1

Antigène: LIM Domain Kinase 1 (LIMK1)

Autre désignation: LIMK1

Sujet:

Background: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.

Soosairajah J, et al. (2005) EMBO J.
Ohashi K, et al. (2000) J Biol Chem, 275(5): 3577-82.
Edwards DC, et al. (1999) Nat Cell Biol, 1(5): 253-9.

Aliases: EC 2.7.11.1 antibody, LIM domain kinase 1 antibody, LIM motif-containing protein kinase antibody, LIMK antibody, LIMK-1 antibody, limk1 antibody, LIMK1_HUMAN antibody

UniProt: P53667

Pathways: Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events