BLM anticorps (pThr99)

N° du produit ABIN7138888

Cet anticorps anti-BLM est un anticorps Lapin Polyclonal détectant BLM dans WB, ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour BLM anticorps (pThr99) (ABIN7138888)

Antigène: BLM (Bloom Syndrome RecQ Like Helicase (BLM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BLM est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-BLM anticorps

Épitope: pThr99

Fonction: Phospho-BLM (Thr99) Antibody

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of threonine 99 (Q-E-T(p)-Q-R) derived from Human Bloom Syndrome.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BLM

Antigène: BLM (Bloom Syndrome RecQ Like Helicase (BLM))

Autre désignation: BLM

Sujet:

Background:

Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).

Ellis N.A., Cell 83:655-666(1995).
Karow J.K., J. Biol. Chem. 272:30611-30614(1997).
Pichierri P., EMBO J. 23:3154-3163(2004).

Aliases: Blm antibody, BLM_HUMAN antibody, Bloom syndrome antibody, Bloom syndrome protein antibody, Bloom syndrome RecQ helicase like antibody, BS antibody, DNA helicase antibody, DNA helicase RecQ like type 2 antibody, MGC126616 antibody, MGC131618 antibody, MGC131620 antibody, RECQ 2 antibody, RECQ like antibody, RecQ like type 2 antibody, RecQ protein like 3 antibody, RecQ protein-like 3 antibody, RecQ-like type 2 antibody, RecQ2 antibody, RECQL 2 antibody, RECQL 3 antibody, RECQL2 antibody, RECQL3 antibody, type 2 antibody

UniProt: P54132

Pathways: Réparation de l'ADN