CD22 anticorps (pTyr807)

N° du produit ABIN7139074

Cet anticorps anti-CD22 est un anticorps Lapin Polyclonal détectant CD22 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour CD22 anticorps (pTyr807) (ABIN7139074)

Antigène: CD22 (CD22 Molecule (CD22))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD22 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CD22 anticorps

Épitope: pTyr807

Fonction: Phospho-CD22 (Tyr807) Antibody

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 807 (G-D-Y(p)-E-N) derived from Human BL-CAM.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CD22

Antigène: CD22 (CD22 Molecule (CD22))

Autre désignation: CD22

Sujet:

Background:

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Wilson G.L., J. Exp. Med. 173-137-146(1991).
Wilson G.L., J. Immunol. 150:5013-5024(1993).
Stamenkovic I., Nature 345-74-77(1990).

Aliases: B cell receptor CD22 precursor antibody, B lymphocyte cell adhesion molecule antibody, B-cell receptor CD22 antibody, B-lymphocyte cell adhesion molecule antibody, BL CAM antibody, BL-CAM antibody, BLCAM antibody, CD 22 antibody, CD22 antibody, CD22 antigen antibody, CD22 Molecule antibody, CD22 protein antibody, CD22_HUMAN antibody, Lectin 2 antibody, Leu14 antibody, Lyb8 antibody, MGC130020 antibody, sialic acid binding Ig like lectin 2 antibody, Sialic acid binding immunoglobulin like lectin 2 antibody, Sialic acid-binding Ig-like lectin 2 antibody, SIGLEC 2 antibody, Siglec-2 antibody, SIGLEC2 antibody, T cell surface antigen Leu 14 antibody, T-cell surface antigen Leu-14 antibody

UniProt: P20273