Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 1-147) anticorps (HRP)

N° du produit ABIN7141319

Cet anticorps Lapin Polyclonal détecte spécifiquement dans ELISA. Il présente une réactivité envers Epstein-Barr Virus (EBV).

Aperçu rapide pour Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 1-147) anticorps (HRP) (ABIN7141319)

Antigène: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Reactivité: Epstein-Barr Virus (EBV)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: HRP

Application: ELISA

Détail du produit

Épitope: AA 1-147

Virus Strain: strain B95-8

Fonction: LMP2 Antibody, HRP conjugated

Réactivité croisée: Epstein-Barr Virus (EBV)

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Autre désignation: Epstein-Barr virus (strain B95-8) (HHV-4) (Herpex simplex 4) LMP2

Sujet:

Background: Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.

Aliases: LMP2 antibody, Latent membrane protein 2 antibody, Terminal protein antibody

UniProt: P13285