DCLRE1B anticorps (AA 345-493) (Biotin)

N° du produit ABIN7142657

Cet anticorps Lapin Polyclonal détecte spécifiquement DCLRE1B dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour DCLRE1B anticorps (AA 345-493) (Biotin) (ABIN7142657)

Antigène: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLRE1B est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-DCLRE1B anticorps (Biotin)

Épitope: AA 345-493

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human 5\' exonuclease Apollo protein (345-493AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DCLRE1B

Antigène: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Autre désignation: DCLRE1B

Sujet:

Background: 5\'-3\' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3\' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

Aliases: DCLRE1B antibody, SNM1B5' exonuclease Apollo antibody, EC 3.1.-.- antibody, DNA cross-link repair 1B protein antibody, SNM1 homolog B antibody, SNMIB antibody, hSNM1B antibody

UniProt: Q9H816