ATG5 anticorps (AA 5-272) (Biotin)

N° du produit ABIN7145092

Cet anticorps anti-ATG5 est un anticorps Lapin Polyclonal détectant ATG5 dans ELISA. Adapté pour Humain.

Aperçu rapide pour ATG5 anticorps (AA 5-272) (Biotin) (ABIN7145092)

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG5 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-ATG5 anticorps (Biotin)

Épitope: AA 5-272

Fonction: ATG5 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Autophagy protein 5 protein (5-272AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ATG5

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Autre désignation: ATG5

Sujet:

Background: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.

Aliases: APG 5 antibody, APG 5L antibody, APG5 antibody, APG5 autophagy 5 like antibody, APG5 like antibody, APG5-like antibody, APG5L antibody, Apoptosis specific protein antibody, Apoptosis-specific protein antibody, ASP antibody, ATG 5 antibody, Atg5 antibody, ATG5 autophagy related 5 homolog antibody, ATG5_HUMAN antibody, Autophagy protein 5 antibody, Autophagy related 5 antibody, hAPG5 antibody, Homolog of S Cerevisiae autophagy 5 antibody, OTTHUMP00000040507 antibody

UniProt: Q9H1Y0

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy