BBS1 anticorps (AA 217-417) (Biotin)

N° du produit ABIN7145232

L’anticorps Lapin Polyclonal anti-BBS1 a été validé pour ELISA. Il convient pour détecter BBS1 dans des échantillons de Humain.

Aperçu rapide pour BBS1 anticorps (AA 217-417) (Biotin) (ABIN7145232)

Antigène: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BBS1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-BBS1 anticorps (Biotin)

Épitope: AA 217-417

Fonction: BBS1 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Bardet-Biedl syndrome 1 protein (217-417AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BBS1

Antigène: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Autre désignation: BBS1

Sujet:

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Aliases: AI451249 antibody, Bardet-Biedl syndrome 1 antibody, Bardet-Biedl syndrome 1 homolog antibody, Bardet-Biedl syndrome 1 protein antibody, BBS1 antibody, BBS1_HUMAN antibody, BBS2-like protein 2 antibody, BBS2L2 antibody, D19Ertd609e antibody

UniProt: Q8NFJ9

Pathways: Signalisation Hedgehog