BBS7 anticorps (AA 289-393) (HRP)

N° du produit ABIN7145249

Cet anticorps Lapin Polyclonal détecte spécifiquement BBS7 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour BBS7 anticorps (AA 289-393) (HRP) (ABIN7145249)

Antigène: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BBS7 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-BBS7 anticorps (HRP)

Épitope: AA 289-393

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Bardet-Biedl syndrome 7 protein (289-393AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BBS7

Antigène: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Autre désignation: BBS7

Sujet:

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Aliases: Bardet Biedl syndrome 7 protein antibody, Bardet-Biedl syndrome 7 antibody, Bardet-Biedl syndrome 7 protein antibody, BBS2 like 1 antibody, BBS2 like protein 1 antibody, BBS2-like protein 1 antibody, BBS2L1 antibody, BBS7 antibody, BBS7_HUMAN antibody, FLJ10715 antibody

UniProt: Q8IWZ6

Pathways: Signalisation Hedgehog