BATF anticorps (Basic Leucine Zipper ATF-like Transcription Factor) AA 1-125 (Biotin) Primary Antibody
- Antigène Voir toutes BATF Anticorps
- AA 1-125
- Cet anticorp BATF est conjugé à/à la Biotin
- Réactivité croisée
- >95%, Protein G purified
- Recombinant Human Basic leucine zipper transcriptional factor ATF-like protein (1-125AA)
anti-Basic Leucine Zipper ATF-like Transcription Factor (BATF) (Middle Region) antibody Primary Antibody
BATF Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugatedanti-Basic Leucine Zipper ATF-like Transcription Factor (BATF) (N-Term) antibody Primary Antibody
BATF Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugatedanti-Basic Leucine Zipper ATF-like Transcription Factor (BATF) (AA 35-84) antibody Primary Antibody
BATF Reactivité: Humain, Souris, Rat, Roussette (Chauve-souris), Boeuf (Vache), Chien, Cobaye, Hamster, Cheval, Singe, Lapin, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- For Research Use only
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
- Autre désignation
- BATF (BATF Produits)
- B-ATF, si:ch211-153j24.4, BATF1, SFA-2, SFA2, basic leucine zipper transcription factor, ATF-like, basic leucine zipper ATF-like transcription factor, batf, BATF, Batf
Background: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5\'-TGA[CG]TCA-3\'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5\'-TGAnTCA/GAAA-3\'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
Aliases: Activating transcription factor B antibody, B ATF antibody, B-ATF antibody, B-cell-activating transcription factor antibody, Basic leucine zipper transcription factor like antibody, Basic leucine zipper transcriptional factor ATF like antibody, Basic leucine zipper transcriptional factor ATF-like antibody, Batf antibody, BATF_HUMAN antibody, BATF1 antibody, SF HT activated gene 2 protein antibody, SF-HT-activated gene 2 protein antibody, SFA 2 antibody, SFA-2 antibody, SFA2 antibody