MST1R anticorps (pTyr1238) (Cy3)

N° du produit ABIN710339

L’anticorps anti-MST1R Polyclonal Lapin est utilisé pour la détection de MST1R dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour MST1R anticorps (pTyr1238) (Cy3) (ABIN710339)

Antigène: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MST1R est conjugé à/à la Cy3

Application: Western Blotting (WB)

Détail du produit anti-MST1R anticorps (Cy3)

Épitope: pTyr1238

Réactivité croisée: Humain, Singe, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human MST1R around the phosphorylation site of Tyr1238

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MST1R

Antigène: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Autre désignation: Ron

Sujet:

Synonyms: RON, PTK8, CD136, CDw136, Macrophage-stimulating protein receptor, MSP receptor, Protein-tyrosine kinase 8, p185-Ron, MST1R

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

ID gène: 4486

UniProt: Q04912

Pathways: Signalisation RTK