KCTD6 anticorps (AA 1-237) (Biotin)

N° du produit ABIN7145857

Cet anticorps anti-KCTD6 est un anticorps Lapin Polyclonal détectant KCTD6 dans ELISA. Adapté pour Humain.

Aperçu rapide pour KCTD6 anticorps (AA 1-237) (Biotin) (ABIN7145857)

Antigène: KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCTD6 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-KCTD6 anticorps (Biotin)

Épitope: AA 1-237

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KCTD6

Antigène: KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))

Autre désignation: KCTD6

Sujet:

Background: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).

Aliases: BTB/POZ domain-containing protein KCTD6 antibody, KCASH3 antibody, kctd6 antibody, KCTD6_HUMAN antibody, MGC27385 antibody, potassium channel tetramerization domain containing 6 antibody

UniProt: Q8NC69