KCTD6 anticorps (AA 1-237) (Biotin)

N° du produit ABIN7145857

Détail du produit anti-KCTD6 anticorps (Biotin)

Antigène: KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))

Épitope: AA 1-237

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCTD6 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KCTD6

Antigène: KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))

Autre désignation: KCTD6 (KCTD6 Produits)

Synonymes: anticorps KCTD6, anticorps 5430433B02Rik, anticorps AU044285, anticorps kctd6, anticorps zgc:91884, anticorps KCASH3, anticorps potassium channel tetramerization domain containing 6, anticorps potassium channel tetramerisation domain containing 6, anticorps potassium channel tetramerization domain containing 6b, anticorps KCTD6, anticorps kctd6, anticorps Kctd6, anticorps kctd6b

Sujet:

Background: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).

Aliases: BTB/POZ domain-containing protein KCTD6 antibody, KCASH3 antibody, kctd6 antibody, KCTD6_HUMAN antibody, MGC27385 antibody, potassium channel tetramerization domain containing 6 antibody

UniProt: Q8NC69