EFHA1 anticorps (AA 26-247)

N° du produit ABIN7146326

Cet anticorps Lapin Polyclonal détecte spécifiquement EFHA1 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour EFHA1 anticorps (AA 26-247) (ABIN7146326)

Antigène: EFHA1 (EF-Hand Domain Family, Member A1 (EFHA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EFHA1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-EFHA1 anticorps

Épitope: AA 26-247

Fonction: MICU2 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EFHA1

Antigène: EFHA1 (EF-Hand Domain Family, Member A1 (EFHA1))

Autre désignation: MICU2

Sujet:

Background: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).

Aliases: 1110008L20Rik antibody, EF hand domain containing family member A1 antibody, EF hand domain family A1 antibody, EF hand domain family member A1 antibody, EF-hand domain-containing family member A1 antibody, EFHA1 antibody, EFHA1 EF hand domain family member A1 antibody, EFHA1_HUMAN antibody, FLJ25016 antibody, FLJ34588 antibody, Smhs2 homolog antibody

UniProt: Q8IYU8