CNOT1 anticorps (AA 604-867)

N° du produit ABIN7147089

L’anticorps Lapin Polyclonal anti-CNOT1 a été validé pour ELISA, IHC et IF. Il convient pour détecter CNOT1 dans des échantillons de Humain.

Aperçu rapide pour CNOT1 anticorps (AA 604-867) (ABIN7147089)

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNOT1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-CNOT1 anticorps

Épitope: AA 604-867

Fonction: CNOT1 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human CCR4-NOT transcription complex subunit 1 protein (604-867AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CNOT1

Antigène: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Autre désignation: CNOT1

Sujet:

Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3\'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

Aliases: CNOT1 antibody, CDC39 antibody, KIAA1007 antibody, NOT1 antibody, AD-005CCR4-NOT transcription complex subunit 1 antibody, CCR4-associated factor 1 antibody, Negative regulator of transcription subunit 1 homolog antibody, NOT1H antibody, hNOT1 antibody

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance