CETN2 anticorps (AA 1-172)

N° du produit ABIN7147353

Détail du produit anti-CETN2 anticorps

Antigène: CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))

Épitope: AA 1-172

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CETN2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Centrin-2 protein (1-172AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CETN2

Antigène: CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))

Autre désignation: CETN2 (CETN2 Produits)

Synonymes: anticorps cb732, anticorps CETN2, anticorps 1110034A02Rik, anticorps AI326150, anticorps Calt, anticorps caltractin, anticorps CALT, anticorps CEN2, anticorps caltractin, anticorps centrin 2, anticorps centrin 4, anticorps LOC412449, anticorps CETN2, anticorps cetn4, anticorps Cetn2

Sujet:

Background: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5\\\'-to-3\\\' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.

Aliases: 20kD calcium binding protein antibody, CALT antibody, caltractin antibody, Caltractin isoform 1 antibody, CEN2 antibody, centrin antibody, centrin, EF hand protein, 2 antibody, Centrin-2 antibody, Centrin2 antibody, CETN2 antibody, CETN2_HUMAN antibody, EF hand protein 2 antibody, EF-hand protein antibody

UniProt: P41208

Pathways: Réparation de l'ADN, M Phase