DMAP1 anticorps (AA 250-300) (Biotin)

N° du produit ABIN7150198

Cet anticorps anti-DMAP1 est un anticorps Lapin Polyclonal détectant DMAP1 dans ELISA. Adapté pour Humain.

Aperçu rapide pour DMAP1 anticorps (AA 250-300) (Biotin) (ABIN7150198)

Antigène: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMAP1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-DMAP1 anticorps (Biotin)

Épitope: AA 250-300

Fonction: DMAP1 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human DNA methyltransferase 1-associated protein 1 protein (250-300AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DMAP1

Antigène: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Autre désignation: DMAP1

Sujet:

Background: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.

Aliases: DMAP1 antibody, KIAA1425DNA methyltransferase 1-associated protein 1 antibody, DNMAP1 antibody, DNMT1-associated protein 1 antibody

UniProt: Q9NPF5