PIAS4 anticorps (AA 66-241)

N° du produit ABIN7150970

Cet anticorps Lapin Polyclonal détecte spécifiquement PIAS4 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour PIAS4 anticorps (AA 66-241) (ABIN7150970)

Antigène: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIAS4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PIAS4 anticorps

Épitope: AA 66-241

Fonction: PIAS4 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human E3 SUMO-protein ligase PIAS4 protein (66-241AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIAS4

Antigène: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Autre désignation: PIAS4

Sujet:

Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Aliases: E3 SUMO protein ligase PIAS4 antibody, E3 SUMO-protein ligase PIAS4 antibody, FLJ12419 antibody, MGC35296 antibody, PAIASgamma antibody, PIAS 4 antibody, PIAS gamma antibody, PIAS-gamma antibody, Pias4 antibody, PIAS4_HUMAN antibody, PIASG antibody, PIASgamma antibody, PIASy antibody, Protein inhibitor of activated STAT 4 antibody, Protein inhibitor of activated STAT protein 4 antibody, Protein inhibitor of activated STAT protein gamma antibody, Protein inhibitor of activated STAT protein PIASy antibody, Zinc finger MIZ type containing 6 antibody, ZMIZ 6 antibody, ZMIZ6 antibody

UniProt: Q8N2W9

Pathways: Signalistation JAK/STAT, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus