RNF2 anticorps (AA 158-290)

N° du produit ABIN7151119

Cet anticorps anti-RNF2 est un anticorps Lapin Polyclonal détectant RNF2 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour RNF2 anticorps (AA 158-290) (ABIN7151119)

Antigène: RNF2 (Ring Finger Protein 2 (RNF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-RNF2 anticorps

Épitope: AA 158-290

Fonction: RNF2 Antibody

Réactivité croisée: Souris

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human E3 ubiquitin-protein ligase RING2 protein (158-290AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RNF2

Antigène: RNF2 (Ring Finger Protein 2 (RNF2))

Autre désignation: RNF2

Sujet:

Background: E3 ubiquitin-protein ligase that mediates monoubiquitination of \\\'Lys-119\\\' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.

Aliases: BAP 1 antibody, BAP1 antibody, DING antibody, DinG protein antibody, E3 ubiquitin protein ligase RING 2 antibody, E3 ubiquitin protein ligase RING2 antibody, E3 ubiquitin-protein ligase RING2 antibody, HIP2 interacting protein 3 antibody, HIP2-interacting protein 3 antibody, HIPI 3 antibody, HIPI3 antibody, Huntingtin interacting protein 2 interacting protein 3 antibody, Huntingtin-interacting protein 2-interacting protein 3 antibody, OTTHUMP00000060668 antibody, Polycomb M33 interacting protein Ring 1B antibody, Polycomb M33 interacting protein Ring1B antibody, Protein DinG antibody, RING 1B antibody, RING 2 antibody, RING finger protein 1B antibody, RING finger protein 2 antibody, RING finger protein BAP 1 antibody, RING finger protein BAP-1 antibody, RING finger protein BAP1 antibody, RING1b antibody, RING2_HUMAN antibody, RNF 2 antibody, Rnf2 antibody

UniProt: Q99496