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SIAH1 anticorps (AA 1-313)

SIAH1 Reactivité: Humain ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7151217
  • Antigène Voir toutes SIAH1 Anticorps
    SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
    Épitope
    • 15
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-313
    Reactivité
    • 36
    • 25
    • 24
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 47
    • 2
    • 2
    Lapin
    Clonalité
    • 49
    • 2
    Polyclonal
    Conjugué
    • 19
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SIAH1 est non-conjugé
    Application
    • 43
    • 22
    • 13
    • 13
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
     Réactivité croisée
    Humain
    Purification
    Antigen Affinity Purified
    Immunogène
    Recombinant Human E3 ubiquitin-protein ligase SIAH1 protein (1-313AA)
    Isotype
    IgG
    Top Product
    Discover our top product SIAH1 Anticorps primaire
  • Indications d'application
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
    Autre désignation
    SIAH1 (SIAH1 Produits)
    Synonymes
    anticorps SIAH, anticorps Siah1, anticorps Siah1a, anticorps id:ibd2635, anticorps zgc:56026, anticorps SIAH1A, anticorps siah, anticorps E3 ubiquitin-protein ligase Siah1, anticorps E3 ubiquitin-protein ligase siah-1, anticorps siah E3 ubiquitin protein ligase 1, anticorps siah E3 ubiquitin protein ligase 1 L homeolog, anticorps Tsp_03055, anticorps siah-1, anticorps Siah1, anticorps siah1, anticorps SIAH1, anticorps siah1.L
    Sujet

    Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.

    Aliases: E3 ubiquitin-protein ligase SIAH1 antibody, FLJ08065 antibody, hSIAH1 antibody, HUMSIAH antibody, Seven in absentia homolog 1 (Drosophila) antibody, Seven in absentia homolog 1 antibody, Siah 1 antibody, Siah 1a antibody, Siah E3 ubiquitin protein ligase 1 antibody, Siah-1 antibody, Siah-1a antibody, Siah1 antibody, SIAH1_HUMAN antibody, SIAH1A antibody, Ubiquitin ligase SIAH1 antibody

    UniProt
    Q8IUQ4
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