SMURF2 anticorps (AA 1-748)

N° du produit ABIN7151226

Détail du produit anti-SMURF2 anticorps

Antigène: SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

Épitope: AA 1-748

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMURF2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase SMURF2 protein (1-748AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SMURF2

Antigène: SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))

Autre désignation: SMURF2 (SMURF2 Produits)

Synonymes: anticorps SMURF2, anticorps 2810411E22Rik, anticorps AI558114, anticorps AI649275, anticorps RGD1310067, anticorps wu:fb82a11, anticorps wu:fc41c02, anticorps SMAD specific E3 ubiquitin protein ligase 2, anticorps SMAD specific E3 ubiquitin protein ligase 2 S homeolog, anticorps SMURF2, anticorps smurf2, anticorps Smurf2, anticorps smurf2.S

Sujet:

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Aliases: E3 ubiquitin-protein ligase SMURF2 antibody, EC 6.3.2. antibody, hSMURF2 antibody, MGC138150 antibody, Smad specific E3 ubiquitin ligase 2 antibody, SMAD specific E3 ubiquitin protein ligase 2 antibody, SMAD ubiquitination regulatory factor 2 antibody, SMAD-specific E3 ubiquitin-protein ligase 2 antibody, SMUF2_HUMAN antibody, Smurf2 antibody, Ubiquitin protein ligase SMURF2 antibody

UniProt: Q9HAU4