EPAS1 anticorps (AA 543-870)

N° du produit ABIN7151747

Cet anticorps Lapin Polyclonal détecte spécifiquement EPAS1 dans IHC, ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour EPAS1 anticorps (AA 543-870) (ABIN7151747)

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPAS1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-EPAS1 anticorps

Épitope: AA 543-870

Fonction: EPAS1 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Endothelial PAS domain-containing protein 1 protein (543-870AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EPAS1

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Autre désignation: EPAS1

Sujet:

Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5\'-[AG]CGTG-3\' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Aliases: Basic helix loop helix PAS protein MOP2 antibody, Basic-helix-loop-helix-PAS protein MOP2 antibody, bHLHe73 antibody, Class E basic helix-loop-helix protein 73 antibody, ECYT4 antibody, Endothelial PAS domain containing protein 1 antibody, Endothelial pas domain protein 1 antibody, Endothelial PAS domain-containing protein 1 antibody, EPAS 1 antibody, EPAS-1 antibody, EPAS1 antibody, EPAS1_HUMAN antibody, HIF 1 alpha like factor antibody, HIF 2 alpha antibody, HIF-1-alpha-like factor antibody, HIF-2-alpha antibody, HIF2-alpha antibody, HIF2A antibody, HLF antibody, Hypoxia inducible factor 2 alpha antibody, Hypoxia inducible factor 2 alpha subunit antibody, Hypoxia-inducible factor 2-alpha antibody, Member of PAS protein 2 antibody, Member of pas superfamily 2 antibody, MOP 2 antibody, MOP2 antibody, PAS domain-containing protein 2 antibody, PASD2 antibody

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg