EPH Receptor A8 anticorps (AA 45-249)

N° du produit ABIN7151855

Détail du produit anti-EPH Receptor A8 anticorps

Antigène: EPH Receptor A8 (EPHA8)

Épitope: AA 45-249

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A8 est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Ephrin type-A receptor 8 protein (45-249AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EPH Receptor A8

Antigène: EPH Receptor A8 (EPHA8)

Autre désignation: EPHA8 (EPHA8 Produits)

Synonymes: anticorps TK, anticorps tke17-a, anticorps si:ch211-122l14.1, anticorps EPHA8, anticorps EEK, anticorps EK3, anticorps HEK3, anticorps AW047546, anticorps Eek, anticorps Hek3, anticorps mKIAA1459, anticorps EPH receptor A8 L homeolog, anticorps EPH receptor A8, anticorps eph receptor A8, anticorps Eph receptor A8, anticorps epha8.L, anticorps EPHA8, anticorps epha8, anticorps Epha8

Sujet:

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

Aliases: EPHA8 antibody, EEK antibody, HEK3 antibody, KIAA1459Ephrin type-A receptor 8 antibody, EC 2.7.10.1 antibody, EPH- and ELK-related kinase antibody, EPH-like kinase 3 antibody, EK3 antibody, hEK3 antibody, Tyrosine-protein kinase receptor EEK antibody

UniProt: P29322

Pathways: Signalisation RTK