EPH Receptor B1 anticorps (AA 260-500)

N° du produit ABIN7151859

L’anticorps Lapin Polyclonal anti-EPH Receptor B1 a été validé pour ELISA et IHC. Il convient pour détecter EPH Receptor B1 dans des échantillons de Humain.

Aperçu rapide pour EPH Receptor B1 anticorps (AA 260-500) (ABIN7151859)

Antigène: EPH Receptor B1 (EPHB1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor B1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-EPH Receptor B1 anticorps

Épitope: AA 260-500

Fonction: EPHB1 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Ephrin type-B receptor 1 protein (260-500AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EPH Receptor B1

Antigène: EPH Receptor B1 (EPHB1)

Autre désignation: EPHB1

Sujet:

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

Aliases: Cek 6 antibody, EK6 antibody, ELK antibody, Elkh antibody, EPH receptor B1 antibody, Eph tyrosine kinase 2 antibody, EPH-like kinase 6 antibody, Ephb1 antibody, EPHB1_HUMAN antibody, Ephrin type B receptor 1 antibody, Ephrin type-B receptor 1 antibody, EPHT2 antibody, HEK 6 antibody, HEK6 antibody, NET antibody, Neuronally-expressed EPH-related tyrosine kinase antibody, soluble EPHB1 variant 1 antibody, Tyrosine protein kinase receptor EPH 2 antibody, Tyrosine-protein kinase receptor EPH-2 antibody

UniProt: P54762

Pathways: Signalisation RTK