EXOSC3 anticorps (AA 2-275)

N° du produit ABIN7152285

L’anticorps Lapin Polyclonal anti-EXOSC3 a été validé pour ELISA et IHC. Il convient pour détecter EXOSC3 dans des échantillons de Humain.

Aperçu rapide pour EXOSC3 anticorps (AA 2-275) (ABIN7152285)

Antigène: EXOSC3 (Exosome Component 3 (EXOSC3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-EXOSC3 anticorps

Épitope: AA 2-275

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Exosome complex component RRP40 protein (2-275AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EXOSC3

Antigène: EXOSC3 (Exosome Component 3 (EXOSC3))

Autre désignation: EXOSC3

Sujet:

Background: Non-catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.

Aliases: EXOSC3 antibody, RRP40 antibody, CGI-102Exosome complex component RRP40 antibody, Exosome component 3 antibody, Ribosomal RNA-processing protein 40 antibody, p10 antibody

UniProt: Q9NQT5

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome