FBXW11 anticorps (AA 1-140)

N° du produit ABIN7152490

Cet anticorps anti-FBXW11 est un anticorps Lapin Polyclonal détectant FBXW11 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour FBXW11 anticorps (AA 1-140) (ABIN7152490)

Antigène: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW11 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-FBXW11 anticorps

Épitope: AA 1-140

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human F-box/WD repeat-containing protein 11 protein (1-140AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FBXW11

Antigène: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Autre désignation: FBXW11

Sujet:

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Aliases: beta Transducin Repeat Containing Protein 2 antibody, BTRC2 antibody, BTRCP2 antibody, F-box and WD repeats protein beta-TrCP2 antibody, F-box and WD-40 Domain Protein 1B antibody, F-box Protein FBW1B antibody, F-box/WD repeat-containing protein 11 antibody, F-box/WD repeat-containing protein 1B antibody, FBW1B antibody, FBW1B_HUMAN antibody, FBXW11 antibody, FBXW1B antibody, Homologous to Slimb protein antibody, HOS antibody

UniProt: Q9UKB1