VAV3 anticorps (AA 562-674) (FITC)

N° du produit ABIN7154662

Cet anticorps anti-VAV3 est un anticorps Lapin Polyclonal détectant VAV3 dans . Adapté pour Humain.

Aperçu rapide pour VAV3 anticorps (AA 562-674) (FITC) (ABIN7154662)

Antigène: VAV3 (Vav 3 Oncogene (VAV3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VAV3 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-VAV3 anticorps (FITC)

Épitope: AA 562-674

Fonction: VAV3 Antibody, FITC conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Guanine nucleotide exchange factor VAV3 protein (562-674AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VAV3

Antigène: VAV3 (Vav 3 Oncogene (VAV3))

Autre désignation: VAV3

Sujet:

Background: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Aliases: FLJ40431 antibody, Guanine nucleotide exchange factor VAV3 antibody, Protein vav 3 antibody, Protein vav3 antibody, RGD1565941 antibody, VAV 3 antibody, Vav 3 guanine nucleotide exchange factor antibody, VAV 3 oncogene antibody, VAV 3 protein antibody, VAV-3 antibody, Vav3 antibody, VAV3 oncogene antibody, VAV3 protein antibody, VAV3_HUMAN antibody

UniProt: Q9UKW4

Pathways: Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway