HSPA1L anticorps (AA 420-641)

N° du produit ABIN7154847

L’anticorps Lapin Polyclonal anti-HSPA1L a été validé pour WB, IHC, ELISA et IF. Il convient pour détecter HSPA1L dans des échantillons de Humain.

Aperçu rapide pour HSPA1L anticorps (AA 420-641) (ABIN7154847)

Antigène: HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSPA1L est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-HSPA1L anticorps

Épitope: AA 420-641

Fonction: HSPA1L Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Heat shock 70 kDa protein 1-like protein (420-641AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HSPA1L

Antigène: HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))

Autre désignation: HSPA1L

Sujet:

Background: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).

Aliases: Heat shock 70 kDa protein 1 Hom antibody, Heat shock 70 kDa protein 1 like antibody, Heat shock 70 kDa protein 1-Hom antibody, Heat shock 70 kDa protein 1-like antibody, Heat shock 70 kDa protein 1L antibody, Heat shock 70kD protein like 1 antibody, HS71L_HUMAN antibody, HSP70 1L antibody, HSP70 HOM antibody, HSP70-Hom antibody, HSPA1L antibody, hum70t antibody, Spermatid specific heat shock protein 70 antibody

UniProt: P34931