HSPA1L anticorps (AA 420-641)

N° du produit ABIN7154847

Détail du produit anti-HSPA1L anticorps

Antigène: HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))

Épitope: AA 420-641

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSPA1L est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Heat shock 70 kDa protein 1-like protein (420-641AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HSPA1L

Antigène: HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))

Autre désignation: HSPA1L (HSPA1L Produits)

Synonymes: anticorps Hsc70t, anticorps Msh5, anticorps HSPA1L, anticorps hspa1l, anticorps MGC147483, anticorps Hsp70-3, anticorps HSP70-1L, anticorps HSP70-HOM, anticorps HSP70T, anticorps hum70t, anticorps heat shock 70kDa protein 1-like, anticorps heat shock protein 1-like, anticorps heat shock 70 kDa protein 1-like, anticorps heat shock protein family A (Hsp70) member 1 like, anticorps HSPA1L, anticorps Hspa1l, anticorps LOC471967, anticorps hspa1l, anticorps LOC474850, anticorps LOC102177850, anticorps LOC100050904

Sujet:

Background: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).

Aliases: Heat shock 70 kDa protein 1 Hom antibody, Heat shock 70 kDa protein 1 like antibody, Heat shock 70 kDa protein 1-Hom antibody, Heat shock 70 kDa protein 1-like antibody, Heat shock 70 kDa protein 1L antibody, Heat shock 70kD protein like 1 antibody, HS71L_HUMAN antibody, HSP70 1L antibody, HSP70 HOM antibody, HSP70-Hom antibody, HSPA1L antibody, hum70t antibody, Spermatid specific heat shock protein 70 antibody

UniProt: P34931