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HAP1 anticorps (AA 328-580) (FITC)

HAP1 Reactivité: Humain Hôte: Lapin Polyclonal FITC
N° du produit ABIN7155935
  • Antigène Voir toutes HAP1 Anticorps
    HAP1 (Huntingtin Associated Protein 1 (HAP1))
    Épitope
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 328-580
    Reactivité
    • 12
    • 6
    • 5
    Humain
    Hôte
    • 11
    • 4
    • 2
    Lapin
    Clonalité
    • 14
    • 3
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    Cet anticorp HAP1 est conjugé à/à la FITC
    Application
    Veuillez nous consulter SVP
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Huntingtin-associated protein 1 protein (328-580AA)
    Isotype
    IgG
    Top Product
    Discover our top product HAP1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    HAP1 (Huntingtin Associated Protein 1 (HAP1))
    Autre désignation
    HAP1 (HAP1 Produits)
    Synonymes
    anticorps HAP2, anticorps HIP5, anticorps HLP, anticorps hHLP1, anticorps HAP1-A, anticorps HAP1-B, anticorps HAP-1, anticorps huntingtin associated protein 1, anticorps huntingtin-associated protein 1, anticorps HAP1, anticorps Hap1
    Sujet

    Background: Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion, the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses, the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs, sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).

    Aliases: HAP 1 antibody, HAP 1A antibody, HAP 2 antibody, HAP-1 antibody, Hap1 antibody, HAP1_HUMAN antibody, HAP2 antibody, HAPP antibody, hHAP1 antibody, hHLP1 antibody, HIP 5 antibody, HIP5 antibody, HLP antibody, HLP1 antibody, Huntingtin associated protein 1A antibody, Huntingtin-associated protein 1 antibody, huntingtin-associated protein 2 antibody, Neuroan 1 antibody, Neuroan1 antibody, OTTHUMP00000164746 antibody, OTTHUMP00000164747 antibody, OTTHUMP00000232821 antibody, OTTHUMP00000232822 antibody

    UniProt
    P54257
    Pathways
    Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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