ALOXE3 anticorps (AA 1-280)

N° du produit ABIN7155980

Cet anticorps Lapin Polyclonal détecte spécifiquement ALOXE3 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour ALOXE3 anticorps (AA 1-280) (ABIN7155980)

Antigène: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALOXE3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ALOXE3 anticorps

Épitope: AA 1-280

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Hydroperoxide isomerase ALOXE3 protein (1-280AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ALOXE3

Antigène: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Autre désignation: ALOXE3

Sujet:

Background: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

Aliases: ALOXE3 antibody, Arachidonate lipoxygenase 3 antibody, e LOX 3 antibody, E LOX antibody, e-LOX-3 antibody, eLOX3 antibody, Epidermal lipoxygenase antibody, Epidermis-type lipoxygenase 3 antibody, Lipoxygenase 3 antibody, LOXE3_HUMAN antibody

UniProt: Q9BYJ1

Pathways: Cell-Cell Junction Organization