HIC1 anticorps (AA 297-418)

N° du produit ABIN7156016

Cet anticorps Lapin Polyclonal détecte spécifiquement HIC1 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour HIC1 anticorps (AA 297-418) (ABIN7156016)

Antigène: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIC1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-HIC1 anticorps

Épitope: AA 297-418

Fonction: HIC1 Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Hypermethylated in cancer 1 protein (297-418AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HIC1

Antigène: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Autre désignation: HIC1

Sujet:

Background: Transcriptional repressor. Recognizes and binds to the consensus sequence \\\'5-[CG]NG[CG]GGGCA[CA]CC-3\\\'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

Aliases: Hic 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, Hic-1 antibody, Hic1 antibody, HIC1_HUMAN antibody, Hypermethylated in cancer 1 antibody, Hypermethylated in cancer 1 protein antibody, ZBTB29 antibody, Zinc finger and BTB domain-containing protein 29 antibody, ZNF901 antibody

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus