IL1RAP anticorps (AA 21-356)

N° du produit ABIN7156734

L’anticorps Lapin Polyclonal anti-IL1RAP a été validé pour IHC et ELISA. Il convient pour détecter IL1RAP dans des échantillons de Humain.

Aperçu rapide pour IL1RAP anticorps (AA 21-356) (ABIN7156734)

Antigène: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL1RAP est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-IL1RAP anticorps

Épitope: AA 21-356

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Interleukin-1 receptor accessory protein (21-356AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IL1RAP

Antigène: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Autre désignation: IL1RAP

Sujet:

Background: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Aliases: C3orf13 antibody, FLJ37788 antibody, IL 1 receptor accessory protein antibody, IL 1R 3 antibody, IL 1R3 antibody, IL 1RAcP antibody, IL 1RAP antibody, IL-1 receptor accessory protein antibody, IL-1R-3 antibody, IL-1R3 antibody, IL-1RAcP antibody, IL-1RAP antibody, IL1 receptor accessory protein antibody, IL1AP_HUMAN antibody, IL1R3 antibody, IL1RAcP antibody, Il1rap antibody, Interleukin 1 Accessory Protein antibody, interleukin 1 receptor 3 antibody, Interleukin 1 receptor accessory protein antibody, interleukin 1 receptor accessory protein beta antibody, Interleukin-1 receptor 3 antibody, Interleukin-1 receptor accessory protein antibody

UniProt: Q9NPH3

Pathways: Signalisation NF-kappaB, Growth Factor Binding