LOXL2 anticorps (AA 27-121)

N° du produit ABIN7158837

L’anticorps Lapin Polyclonal anti-LOXL2 a été validé pour WB, IHC et ELISA. Il convient pour détecter LOXL2 dans des échantillons de Humain.

Aperçu rapide pour LOXL2 anticorps (AA 27-121) (ABIN7158837)

Antigène: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LOXL2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-LOXL2 anticorps

Épitope: AA 27-121

Fonction: LOXL2 Antibody

Réactivité croisée: Souris, Rat

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Lysyl oxidase homolog 2 protein (27-121AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LOXL2

Antigène: LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

Autre désignation: LOXL2

Sujet:

Background: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated \\\'Lys-4\\\' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Aliases: LOR 2 antibody, LOR2 antibody, LOX L2 antibody, LOXL 2 antibody, LOXL2 antibody, LOXL2_HUMAN antibody, Lysyl oxidase homolog 2 antibody, Lysyl oxidase like 2 antibody, Lysyl oxidase like protein 2 antibody, Lysyl oxidase related 2 antibody, Lysyl oxidase related protein 2 antibody, Lysyl oxidase related protein WS9 14 antibody, Lysyl oxidase-like protein 2 antibody, Lysyl oxidase-related protein 2 antibody, Lysyl oxidase-related protein WS9-14 antibody, WS9 14 antibody

UniProt: Q9Y4K0

Pathways: Chromatin Binding