MBTPS1 anticorps (AA 187-400)

N° du produit ABIN7159372

Cet anticorps anti-MBTPS1 est un anticorps Lapin Polyclonal détectant MBTPS1 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour MBTPS1 anticorps (AA 187-400) (ABIN7159372)

Antigène: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MBTPS1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-MBTPS1 anticorps

Épitope: AA 187-400

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Membrane-bound transcription factor site-1 protease protein (187-400aa)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:100-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MBTPS1

Antigène: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Autre désignation: MBTPS1

Sujet:

Background: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Aliases: Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1), MBTPS1, KIAA0091 S1P SKI1

UniProt: Q14703

Pathways: ER-Nucleus Signaling