KISS1 anticorps (AA 20-138) (Biotin)

N° du produit ABIN7159563

L’anticorps Lapin Polyclonal anti-KISS1 a été validé pour ELISA. Il convient pour détecter KISS1 dans des échantillons de Humain.

Aperçu rapide pour KISS1 anticorps (AA 20-138) (Biotin) (ABIN7159563)

Antigène: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KISS1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-KISS1 anticorps (Biotin)

Épitope: AA 20-138

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Metastasis-suppressor KiSS-1 protein (20-138AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KISS1

Antigène: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Autre désignation: KISS1

Sujet:

Background: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

Aliases: KISS 1 antibody, KiSS 1 metastasis suppressor antibody, Kiss1 antibody, KISS1_HUMAN antibody, Kisspeptin 1 antibody, Kisspeptin 10 antibody, Kisspeptin 13 antibody, Kisspeptin 14 antibody, Kisspeptin antibody, Kisspeptin-1 antibody, Kisspeptin-10 antibody, Kisspeptin-54 antibody, Kisspeptin1 antibody, Malignant melanoma metastasis suppressor antibody, Metastasis suppressor KiSS 1 antibody, Metastasis suppressor KiSS1 antibody, Metastin antibody, MGC39258 antibody

UniProt: Q15726

Pathways: Positive Regulation of Peptide Hormone Secretion